Arizona Cardinals at New York Giants odds, picks and best bets

The Arizona Cardinals (2-3-1) take on the New York Giants (2-4) at MetLife Stadium Sunday with a 1 p.m. ET kickoff in Week 7. Below, we break down the Cardinals vs. Giants odds and lines, with NFL betting picks and tips.

Cardinals at Giants: Preview, betting trends and notes


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  • Arizona is 4-2 against the spread while New York is just 2-4.
  • The Cardinals have won three of the last five meetings, but New York holds an 80-44-2 all-time record.
  • The Giants are 1-2 straight up and 1-2 ATS at home, while the Cardinals are 1-1 SU and 1-1 ATS on the road.
  • Giants QB Daniel Jones looked like a rookie quarterback against New England – throwing three interceptions.
  • Cardinals QB Kyler Murray has thrown for 1,664 yards, seven touchdowns and four interceptions on the season while completing over 64% of his passes.
  • The score has gone Over in five of the previous six Giants games against an NFC opponent.
  • The Over/Under has connected in four of six games for Arizona overall.

Cardinals at Giants: Key injuries

Giants star RB Saquon Barkley (ankle) fully participated in practice and is expected to play Sunday.

Cardinals RB David Johnson (hamstring) is questionable but has not practiced yet this week.

Cardinals at Giants:Odds, betting lines and prediction

Oct 13, 2019; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) celebrates a touchdown catch with Arizona Cardinals wide receiver Trent Sherfield (16) against the Atlanta Falcons during the second half at State Farm Stadium. Mandatory Credit: Joe Camporeale-USA TODAY Sports

Oct 13, 2019; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) celebrates a touchdown catch with Arizona Cardinals wide receiver Trent Sherfield (16) against the Atlanta Falcons during the second half at State Farm Stadium. (Photo Credit: Joe Camporeale – USA TODAY Sports)

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 10 a.m. ET.

Prediction

Giants 27, Cardinals 21

Moneyline ( ?)

The GIANTS are a reasonable -154 on the moneyline. Exploit the value before the weekend in case the line drops.

Against the Spread ( ?)

The Giants -2.5 (-129) is the safest play due to the return of Barkley. That adds instant balance to the New York offense and can keep Murray and the Cardinals off the field. If Jones is the player we saw with Barkley in the lineup then the Giants should be able to pick apart the Cardinals defense.

New to sports betting? For the Giants to cover the spread, they need to win the game by three or more points. It would turn a $10 bet into a $7.75 profit.

Over/Under ( ?)

The projected total of 49.5 is a very close number. Weather should not be an issue Sunday as little wind is expected with mild temperatures. Betting the UNDER (+105) is the way to go.

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